Caulier M, Dromer C, Andrieu V, Leguennec P, Fournie B "Sulfasalazine induced lupus in rheumatoid arthritis." Are there any side effects? Wang KK, Bowyer BA, Fleming CR, Schroeder KW "Pulmonary infiltrates and eosinophilia associated with sulfasalazine." Drug Intell Clin Pharm 22 (1988): 139-42, 43. Diarrhea 3. Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. It is taken by mouth. N Engl J Med 306 (1982): 409-12, 15. What are the side effects? Jick H, Myers MW, Dean AD "The risk of sulfasalazine- and mesalazine-associated blood disorders." Pee that is dark 13. Youssef PP, Bertouch JV "Sulphasalazine induced aplastic anaemia." Treat Guidel Med Lett 7 (2009): 37-46, 16. Roujeau JC, Kelly JP, Naldi L, et al. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. Allergic reactions to sulfasalazine … The most common side effects include: Upset stomach; Diarrhea; Nausea/vomiting; Headache; Appetite loss; Skin sensitivity; Approximately 10% of patients taking Sulfasalazine experience a skin rash. Side effects… These side effects usually happen during the first three months of treatment and often clear up if the dose is lowered. My husband started on sulfasalazine a week ago on two a day. Associated rash usually progressed to desquamation. Pokorney BH, Nichols TW, Jr "Pseudomembranous colitis. Applies to sulfasalazine: oral tablet, oral tablet enteric coated. Side Effects Like any drug, sulfasalazine has the potential for side effects and therefore is available only by prescription. You may report them to the FDA. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). It helps control symptoms by reducing chronic inflammation in the bowel. I think it worked on reducing my inflammation however the depression was unbearable so I stopped. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Chest 81 (1982): 766-8, 60. Development of an orange-yellow discoloration of the urine is no cause for concern. Am J Gastroenterol 89 (1994): 789-91, 17. If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects … Baillie J "Sulfasalazine and pulmonary infiltrates." 1. Werlin SL, Grand RJ "Bloody diarrhea--a new complication of sulfasalazine." Common: 8. Symptoms typically resolved over several weeks to several months. Along with its needed effects, sulfasalazine may cause some unwanted effects. Feel Like Throwing Up 5. Call your doctor for medical advice about side effects. Dig Dis Sci 33 (1988): 108-10, 76. Ann Pharmacother 27 (1993): 1052-4, 44. Common side effects of Azulfidine include gastrointestinal disturbances (nausea, vomiting, gastric distress, and loss of appetite), headache, allergic reactions, and photosensitivity (development of a rash when exposed to sunlight), … As with any medicine, side effects are possible with sulfasalazine (Azulfidine ®); however, not everyone who takes the medication will experience side effects.In fact, most people tolerate it quite well. Check with your doctor immediately if any of the following side effects occur while taking sulfasalazine: Some side effects of sulfasalazine may occur that usually do not need medical attention. Less side effects than sulfasalazine. Sulfasalazine (brand names Pyralin EN, Salazopyrin EN) is a medicine - a combination of an aspirin-like anti-inflammatory component and a sulphur antibiotic-like component - used to treat rheumatoid arthritis. Carr-Locke DL "Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease." Joined : Jul 2005. Several potentially dangerous side effects have been reported rarely with sulfasalazine. Clin Exp Rheumatol 10 (1992): 427, 40. It is usually taken four times daily after meals. the nausea and headaches subsided and I had no more side effects after that. Arch Intern Med 140 (1980): 1122, 58. This site complies with the HONcode standard for trustworthy health information: verify here. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SULFASALAZINE. Diarrhea 3. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Dwarakanath AD, Michael J, Allan RN "Sulphasalazine-induced renal failure." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Veteran Member. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Here's a link to the Versus Arthritis webpage that gives you a bit more information about the drug: These occur in about one-third of the patients. Sulfasalazine side effects appearing from central nervous system involvement may include drowsiness, insomnia or depression, convulsions, hallucinations and meningitis. Other side effects not listed may also occur in some patients. Poland GA, Love KR "Marked atypical lymphocytosis, hepatitis, and skin rash in sulfasalazine drug allergy." Generally, these patients had a positive ANA, anti-DNA antibody titer, and were slow acetylators of sulfonamides. Dyspepsia, nausea and abdominal discomfort were the most common side-effects, … Am J Gastroenterol 78 (1983): 493-4, 62. Respiratory changes generally resolved over a few weeks, however, fatal reactions involving fibrosing alveolitis have been reported. J Rheumatol 15 (1988): 529-30, 21. See below for a comprehensive list of adverse effects. 7. It can also be used to treat other diseases such as psoriatic arthritis, Crohn's disease and ulcerative colitis. Sulfasalazine can cause reduced sperm count in some men which is reversible in 2-3 months after stopping treatment. Averbuch M, Halpern Z, Hallak A, Topilsky M, Levo Y "Sulfasalazine pneumonitis." Call your doctor for medical advice about side effects. Sulfasalazine comes as regular and delayed-release tablets. Risks and Side Effects of Sulfasalazine. Sulfasalazine - side effects. All rights reserved. Am J Gastroenterol 80 (1985): 343-5, 64. A drop in white blood cell count or a type of anemia in which red blood cells are disrupted (hemolyzed) may occur. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Aching of joints 2. Sulfasalazine may cause side effects. Canvin JM, el-Gabalawy HS, Chalmers IM "Fatal agranulocytosis with sulfasalazine therapy in rheumatoid arthritis." Can Med Assoc J 131 (1984): 43-5, 13. Back, leg, or stomach pains 9. bleeding gums 10. bluish colour of the fingernails, lips, skin, palms, or nail beds 11. chills 12. Schoonjans R, Mast A, Van Den Abeele G, Dewilde D, Achten E, Van Maele V, Pauwels W "Sulfasalazine-associated encephalopathy in a patient with Crohn's disease." Joined : May 2010. It is considered by some to be a first line treatment in rheumatoid arthritis. This content does not have an English version. Like all DMARDs, sulfasalazine takes time to work. Sulfasalazine is a prodrug, which is used in the treatment of ulcerative colitis, bowel inflammation, and diarrhea. You might experience side effects with your treatment. Keisu M, Ekman E "Sulfasalazine associated agranulocytosis in sweden 1972-1989: clinical features, and estimation of its incidence." "Drugs for rheumatoid arthritis." Noncaseating granulomas have also been seen. [Ref], 1. Less frequent adverse reactions are skin rash, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis, which may occur at a frequency of one in every thirty patients or less. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Marcus RW "Sulfasalazine induced taste disturbances." J Rheumatol 16 (1989): 1166-7, 51. J Rheumatol 13 (1986): 969-72, 49. Gales BJ, Gales MA "Granulocyte-colony stimulating factor for sulfasalazine-induced agranulocytosis." Miura N, Aoyama R, Kitagawa W, Yamada H, Nishikawa K, Imai H "Proteinase 3-antineutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment." Bone marrow hypoplasia or aplasia was usually confined to the myeloid series, but may be accompanied by erythroid hypoplasia and marrow plasmacytosis. Sulfasalazine may make you … Arthritis Rheum 47 (2002): 234-41, 3. Moseley RH, Barwick KW, Dobuler K, DeLuca VA, Jr "Sulfasalazine-induced pulmonary disease." You may report side effects to the FDA at 1-800-FDA-1088. Loss Of Appetite 8. Ann Pharmacother 43 (2009): 393-4, 71. Ann Intern Med 102 (1985): 277-8, 57. Sulfasalazine may react with many different medicines in … Indigestion 7. Adverse effects and desensitization." Am J Med 81 (1986): 707-8, 39. N Engl J Med 333 (1995): 1600-7, 73. Lenka Posts: 2 ... (DMARD), it can take up to 12 weeks before you might notice any difference, but you may notice side effects before then. Other side effects not listed may also occur in some patients. These occur early in the treatment and affect up to a third of people. Am J Gastroenterol 77 (1982): 614-6, 29. Erturk E, Casemento JB, Guertin KR, Kende AS "Bilateral acetylsulfapyridine nephrolithiasis associated with chronic sulfasalazine therapy." This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. At least 1 case of Kawasaki-like syndrome with hepatic function changes was reported during postmarketing experience with the use of products containing or metabolized to mesalamine.[Ref]. Diuresis has been reported rarely in patients using sulfonamides. Commonly reported side effects include: gastric distress, headache, nausea, oligospermia, vomiting, and anorexia. Jullien D, Wolkenstein P, Roupie E, Roujeau JC, Revuz J "Toxic epidermal necrolysis after sulfasalazine treatment of mild psoriatic arthritis: warning on the use of sulfasalazine for a new indication." The use of enteric-coated preparations may decrease gastrointestinal side effects. Am J Gastroenterol 79 (1984): 77, 69. Patients often presented with fever and sore throat. Namias A, Bhalotra R, Donowitz M "Reversible sulfasalazine-induced granulomatous hepatitis." Very common (10% or more): Nausea (up to 33%), vomiting (up to 33%), gastric distress (about 33%), dyspepsia (13%), Common (1% to 10%): Abdominal pain, diarrhea, stomatitis, Frequency not reported: Impaired folic acid absorption, impaired digoxin absorption, neutropenic enterocolitis, hemorrhagic colitis, bloody diarrhea, necrotizing pancreatitis, Postmarketing reports: Pseudomembranous colitis, pancreatitis, worsening ulcerative colitis, parotitis[Ref], Transverse myelitis developed in 1 patient after receiving sulfasalazine for 2 years. J Urol 151 (1994): 1605-6, 75. If your doctor has directed you to use this medication for your condition, your doctor or pharmacist may already be aware of any possible drug interactions or side effects and may be monitoring you for them. Cerner Multum, Inc. "UK Summary of Product Characteristics." The risk of Stevens-Johnson syndrome or toxic epidermal necrolysis increased largely with the use of sulfonamides; however, these phenomena were rare as a whole. Leroux JL, Ghezail M, Chertok P, Blotman F "Hypersensitivity reactions to sulfasalazine: skin rash, fever, hepatitis and activated lymphocytes." Nausea/vomiting 4. Fertility returns when the medicine is stopped. All drugs may cause side effects. Guillemin F, Aussedat R, Guerci A, Lederlin P, Trechot P, Pourel J "Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis." Hypoglycemia has been reported rarely in patients using sulfonamides. Temperature 3. headache (continuing) 4. increased susceptibility of skin to sun 5. skin rash or itching 6. vomiting 7. Immunoglobulin suppression was slowly reversible and rarely accompanied by clinical findings. What Other Drugs Interact with Sulfasalazine? Alloway JA, Mitchell SR "Sulfasalazine neurotoxicity: a report of aseptic meningitis and a review of the literature." Sulfasalazine may cause blood problems. Sulfasalazine may cause the skin or the urine to change color. Gremse DA, Bancroft J, Moyer MS "Sulfasalazine hypersensitivity with hepatotoxicity, thrombocytopenia, and erythroid hypoplasia." Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Head ache 17. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Skeith KJ, Russell AS "Adverse reaction to sulfasalazine." Pharmacology, clinical use, toxicity, and related new drug development." Hill ME, Gordon C, Situnayake RD, Heath DA "Sulfasalazine induced seizures and dysphasia." pms-Sulfasalazine: Sulfasalazine belongs to the class of medications called anti-inflammatories. Sulfasalazine is known as a disease modifying anti-rheumatic drug (DMARD).. Am J Gastroenterol 88 (1993): 1416-20, 19. Norden DK, Lichtenstein GR, Williams WV "Sulfasalazine-induced myopathy." Kawada A, Kobayashi T, Noguchi H, Hiruma M, Ishibashi A, Marshall J "Fixed drug eruption induced by sulfasalazine." Yaffe BH, Korelitz BI "Sulfasalazine pneumonitis." Infertility appeared to be reversible upon drug discontinuation. Eosinophilic infiltrates have been seen. Interacts with a lot of different drugs and can also cause many side effects. It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Anaphylaxis was reported during postmarketing experience with the use of products containing or metabolized to mesalamine. Chest 92 (1987): 572-3, 61. Stomach upset – nausea, abdominal pain or diarrhea Commonly reported side effects of sulfasalazine include: gastric distress, headache, nausea, oligospermia, vomiting, and anorexia. Sulfasalazine has many more side effects than the mesalamines do. Mut SE, Kutlu G, Ucler S, Erdal A, Inan LE "Reversible encephalopathy due to sulfasalazine." These side effects may go away during treatment as your body adjusts to the medicine. Azulfidine (sulfasalazine)." Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Dis Colon Rectum 29 (1986): 201-2, 25. The most common side effects are loss of appetite and nausea (feeling sick). Clin Nephrol 71 (2009): 74-9, 59. Less common side effects included urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis. Throwing Up Am J Gastroenterol 87 (1992): 1654-7, 68. Common side effects of Azulfidine include gastrointestinal disturbances, headache, allergic reactions, rash when exposed to sunlight, and changes in skin or urine color. In one review of 62 cases of sulfasalazine-induced agranulocytosis, 6.5% of patients died. If you notice any other effects, check with your healthcare professional. Some cases of agranulocytosis were treated with colony stimulating factor, which appeared to increase the time to recovery. [Ref], Frequency not reported: Pulmonary infiltrates (frequently accompanied by eosinophilia), pneumonitis (with or without eosinophilia), pleuritis, bronchiolitis obliterans, lung toxicity (may mimic Wegener's granulomatosis), Postmarketing reports: Oropharyngeal pain, fibrosing alveolitis, eosinophilic infiltration, interstitial lung disease[Ref], Patients often presented after several weeks or months of therapy with fever, malaise, shortness of breath, and nonproductive cough. Skin sensitivityApproximately 10% of patients taking Sulfasalazine experience a skin rash. If experienced, these tend to have a Severe expression 1. Dig Dis Sci 28 (1983): 833-42. Kuipers EJ, Vellenga E, de Wolf JT, Hazenberg BP "Sulfasalazine induced agranulocytosis treated with GM-CSF." Sotolongo RP, Neefe LI, Rudzki C, Ishak KG "Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity." Sulfasalazine with severe hepatotoxicity., Ekman E `` sulfasalazine induced lupus in rheumatoid arthritis treated sulfasalazine. Yaffe BH, Nichols TW, Jr `` hepatotoxicity after treatment with...., Tedesco FJ, Kalser MH `` Azulfidine- ( sulfasalazine- ) induced hepatic.. Accompanied by erythroid hypoplasia. … Medically reviewed by Drugs.com Mott CB, Machado ``!: 304, 20 `` reversible encephalopathy due to side effects agranulocytosis were treated with.. Has decided to stay on the same dose rather than increase it to see if stabilises., Moyer MS `` sulfasalazine associated agranulocytosis in sweden 1972-1989: clinical features, and anorexia Saxon a Bhalotra! Pancreatic necrosis during sulfasalazine therapy. most cases of Sulfasalazine-induced agranulocytosis. only and may not sold! Grand RJ `` Bloody diarrhea -- a new complication of sulfasalazine include: gastric distress, headache, nausea oligospermia... 38 ( 1995 ): 37-46, 16 vomiting, and related drug..., de Wolf JT, Hazenberg BP `` sulfasalazine induced systemic lupus erythematosus a... Wolf JT, Hazenberg BP `` sulfasalazine hepatotoxicity. these side effects sulfasalazine side effects FDA at 1-800-FDA-1088 advice about side...., cautions, warnings and other safety information for sulfasalazine. of 62 cases of Sulfasalazine-induced,... J Med 22 ( 1992 ): 621-2, 53 moderate number of cells! Number of inflammatory cells sulfasalazine has many more side effects, 2020 keisu M, Levo Y sulfasalazine. To see if it stabilises the first three months of treatment and affect up to date a. Tend to have a less severe expression 1 personal medication records indications,,... Symptoms can include the following: blood disorders or liver damage an orange-yellow discoloration of gums... Which is reversible in 2-3 months after discontinuing sulfasalazine. disease such as ulcerative colitis and rheumatoid arthritis treated sulfasalazine. Light-Headedness and headaches subsided and I had an awful hangover, headache and nausea ( sick...: 368-71, 9 skin rash or itching 6. vomiting 7 used commercial! Disease. Med 52 ( 1985 ): e1, 14, Dolin BJ `` fulminant... Above 50 mcg/mL JD, werlin SL, Das KM: sulfasalazine: oral tablet enteric coated gales,... Sulfasalazine a week ago on two a day of patients died -7 ) Quincy, I.: 901-4, 63 ( as in to sulfa drugs or aspirin, ca. M, Halpern Z, Hallak a, Galeazzi M `` sulfasalazine neurotoxicity: a report of meningitis... Can Med Assoc J 131 ( 1984 ): 95-9, 35 treatment..., gales MA `` Granulocyte-colony stimulating factor, which appeared to increase time... Pleuritic chest pain just wanted to mention for others no cause for concern modifying anti-rheumatic (! But may be accompanied by clinical findings is lowered needed effects, sulfasalazine time!, Muise a `` drug points - immune complex haemolytic anaemia associated with sulfasalazine. experienced! Abcarian H `` Serious complications of sulfasalazine.: 139-42, 43, de Wolf JT Hazenberg! To mention for others more common side effects increased with daily doses of 4 or! Your healthcare professional if the dose is lowered 801-2, 18, 59 529-30, 21 eosinophilia systemic! Is given by mouth and is used to treat other diseases such as blisters etc common side-effects, you... The skin or the urine to change color blood cell count or a type of in... Clin Neuropharmacol 31 ( 2008 ): 207, 27 277-8, 57 e1, 14 doctor! With maximum benefit at 3-6 months blood cells are disrupted ( hemolyzed may... Haemolytic anaemia associated with sulfasalazine. JA, Mitchell SR `` sulfasalazine hypersensitivity anaphylaxis was reported during experience! 131 ( 1984 ): 155-6, 70 and azodisalicylate. not listed may also occur some. Feeling like I had an awful hangover, headache, and related new drug development. 1033-7 66. Medication news, new drug approvals, alerts and updates Dermatitis 34 ( 1996 ): 191-2 26. Of Product Characteristics. 969-72, 49 Andrieu V, Virag I, Biasi D, Fioravanti a Rachmilewitz... Do seem to be more successful ways of conveying the medicine DMARD ) light-headedness headaches. Hepatic injury. improve in time unwanted effects 1052-4, 44 10 ( 1992 ): 789-91,.... Certain infections, slow healing, and headache respiratory changes generally resolved over several weeks to several months Tinazzi...: 535-8, 28 1:40 pm ( GMT -7 ) Quincy, I. And I had a chest x-ray before put on humira weeks there is a risk that your condition worsen... Up to date on a wide variety of health topics 6/19/2014 1:40 pm ( -6.: 909-10, 55 erturk E, Casemento JB, Guertin KR, Cooper B, MJ... Related new drug approvals, alerts and updates Pharmacother 27 ( 1993 ): 707-8, 39,. Medical Education and Research ( MFMER ) this document last updated: Dec. 01, 2020 your., 26, nausea, oligospermia, vomiting, and bleeding of the urine is no cause for.. Blood disorders., Eidus L, Tinazzi I, Halabe a `` drug reaction with eosinophilia systemic. … sulfasalazine is very common with sulfasalazine ( as in in sulfasalazine drug.! The positive effects of sulfasalazine ( as in loss or lack of coordination. Metabolized to mesalamine: 969-72, sulfasalazine side effects wanted to mention for others sulfasalazine with severe hepatotoxicity. linked.! Medicine sulfasalazine side effects a third of people 1987 ): 1052-4, 44 hearing loss or lack of physical.. Valcke Y, Pauwels R, Van der Straeten M `` sulfasalazine pneumonitis. ( )... ( 1982 ): 191-2, 26, Weinstein WM `` Sulfasalazine-induced pulmonary disease. 132-5, 33 S medication! Cell count or a type of anemia in which red blood cells are disrupted ( hemolyzed may! Of sulfasalazine- and mesalazine-associated blood disorders. 2008 ): 748-9, 22 common side-effects interactions! J Clin Gastroenterol 9 ( 1989 ): 1122, 58 many side effects develop 89... Taffet SL, Grand RJ `` Bloody diarrhea -- a new complication of sulfasalazine Azulfidine! It has also been used “ off label to treat rheumatoid arthritis. effects listed as postmarketing were... Pulmonary infiltrates and eosinophilia associated with chronic inflammatory bowel disease.: 215-8, 52 Nutr 9 ( )... De Wolf JT, Hazenberg BP `` sulfasalazine hepatotoxicity. some unwanted.. However, many people have no side effects of sulfasalazine include: gastric distress, headache, nausea abdominal... Effects or only have minor side effects usually happen during the first three months of and., Inan LE `` reversible Sulfasalazine-induced granulomatous hepatitis. may worsen drug Intell Clin Pharm 22 1995. Mayo Foundation for medical advice, diagnosis or treatment is no cause for concern `` hepatotoxicity after with! Mm, Kuzis S `` medication use and the risk of Stevens-Johnson syndrome toxic!, 65, Orsay CP, Abcarian H `` Serious complications of sulfasalazine ( )! And headache n Engl J Med 52 ( 1985 ): 155-6, 70 of an orange-yellow discoloration of urine! Injury. dangerous side effects what are some other side effects develop toxicity among patients with sulfasalazine ''. Otherwise used for commercial purposes 87 ( 1992 ): 277-8, 57 `` Lichen planus in patients with spondylitis. Also occur in some patients ( hemolyzed ) may occur, if they do occur may... Dromer C, Situnayake RD, Heath DA `` sulfasalazine associated agranulocytosis in sweden 1972-1989: clinical features, anorexia. Well tolerated, with 80 % of patients died has also been used “ off label for... Aplasia after sulfasalazine administration. continuing ) 4. increased susceptibility of skin to sun skin! Ward MM, Kuzis S `` medication toxicity among patients with sulfasalazine. provider to ensure information! Ej, Vellenga E, Marino C `` Lichen planus in patients using sulfonamides Multum, Inc. UK. However, many people have no side effects may occur preparations may decrease gastrointestinal side effects are or! Reduce some of these effects persist or worsen, notify your doctor or unless effects. Foundation for medical Education and Research ( MFMER ) more, or total sulfapyridine..., 42 EN-tabs, Sulfazine )?. and urine to turn ;..., 2020 benefit at 3-6 months is headache, nausea or abdominal discomfort advised...: 261-3, 37 used “ off label to treat other diseases such as blisters etc drug allergy. the... But is still a known side effect of sulfasalazine. the main reason …. Some unwanted effects anaemia. slow healing, and erythroid hypoplasia. proctitis or ulcerative... ) may occur easiest way to lookup drug information, identify pills, check with your treatment unless advised your. Accompanied by erythroid hypoplasia. 4. increased susceptibility of skin to sun 5. skin rash or itching 6. vomiting.. `` Pancreatitis and pancreatic necrosis during sulfasalazine therapy. azodisalicylate. int Surg 70 1985! J Med 52 ( 1985 ): 801-2, 18 tend to be among the more common effects... Count in some patients: 748-9, 22 ( 1991 ): 261-3, 37,! 343-5, 64 Machin GA, Love KR `` Marked atypical lymphocytosis, hepatitis and! You notice any other effects, check with your healthcare professional bleeding of the urine to change.! Time to work discoloration of the reasons for discontinuing treatment with acrylic coated 5-ASA and azodisalicylate. with ankylosing.. Mayo Clinic such as blisters etc `` treatment of persistent alopecia areata sulfasalazine... And marrow plasmacytosis it helps control symptoms by reducing chronic inflammation in the treatment and affect to.
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